1. Leverage electronic health data to implement novel population health services and care coordination for complex populations. We embrace big data and technology to design, develop, and deliver economic and effective services for patients in the area of cancer screening and follow-up.

2. Develop intestinal organoids from primary human samples to understand barrier function, systemic inflammation, inflammatory bowel disease, HIV persistence, infection, and microbiome. Approaches employed: organoid models, isolation of epithelial cells, lymphocytes, microbiota, and interventional trials such as fecal transplant.